Endocrine Abstracts

Approximately 10% of the female present with features of hyperandrogenism in their life. It is common in adolescent and childbearing age and less common in menopausal age. A 56-year-old female with a history of type 2 diabetes mellitus, hypertension presented with progressively worsening features of virilization for 1 year. Patient had severe hirsutism, androgenic alopecia and clitoromegaly. She had no loss of weight, loss of appetite suggestive of underlying malignancy. Howev...

Background: Obesity is often complicated by cardiovascular and atherosclerotic disease. Central or visceral obesity is known to be associated with hypertension and cardiovascular disease. Even though BMI is a good indicator of obesity in epidemiological studies, it does not differentiate between lean and fat mass. Furthermore waist circumference (WC) and visceral fat percentages are better indicators of visceral obesity. Aim of this study was to investigate the correlation of ...

Introduction: Idiopathic hypoparathyroidism is a rare endocrine disorder with varying clinical manifestations ranging from acute hypocalcemic symptoms to asymptomatic soft and skeletal tissue calcifications/ossifications. Patients may present with wide spectrum of rheumatological manifestations, which are under-recognized, thus delaying timely treatment. This results in chronic disability.Case presentation: A 47-year-old male with past history of convuls...

Parathyromatosis is a persistent or recurrent hyperparathyroidism following parathyroidectomy. It usually presents as multiple nodules in the neck. Infrequently may present as a single palpable neck mass. It could be due to low grade malignancy, seeding of parathyroid tissue during parathyroidectomy and growth of persistent embryonic foci of parathyroid tissue. A 24-year-old patient presented with features of hypercalcaemia. She has undergone left inferior parathyroidectomy 1 ...

Introduction: Visceral adiposity is shown to be associated with cardiovascular disease. Aim of this study was to evaluate the usefulness of visceral fat percentage (VF%) and body fat percentage (BF%), compared to anthropometric parameters, BMI waist circumference (WC), and waist – hip ratio(WHR) in predicting obesity and cardiovascular risk.Method: A descriptive cross sectional study conducted within five health divisions in Colombo district in Sri ...

Background: Neurofibromatosis 1 (NF-1) is an autosomal-dominant multisystemic neurocutaneous disorder. It has long been appreciated that NF-1 is associated with endocrine conditions. The well reported endocrine conditions in NF-1 are growth hormone deficiency, central precocious puberty, pheochromocytoma and gastrointestinal neuroendocrine tumors including insulinoma. Furthermore, individuals with NF-1 are at increased risk of some malignancies including soft tissue sarcomas, ...

Introduction: Obesity is associated with increased prevalence of cardiovascular(CV) risk factors and mortality and the CV risk factors are known to reduce following bariatric surgery. The aim of this analysis was to determine the effect of bariatric surgery on CV risk factors and CV risk score.Method: A prospective analytical study of the first 15 consecutive patients who underwent laparoscopic Sleeve Gastrectomy procedure from 2009 to 2011 in Colombo. B...

Background: Non-Diabetic Hypoglycemia is a rare entity in Endocrinology. After the confirmation of hypoglycemia with Whipple’s triad and excluding drug induced hypoglycemia, identification of underlying etiology using appropriate and targeted investigations is fundamental to institute specific management. It is challenging in resource poor settings due to unavailability and high cost of some investigations such as insulin autoantibodies and insulin-like growth factr-2 (IG...